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Parameters
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day 1
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day 4
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day 7
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day 14
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ICU stay
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Age [years]
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61 (51–69)
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Body mass index [kg/m2]
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29.3 (25.3–34.6)
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Duration of ICU stay [days]
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23 (14–34)
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Duration of mechanical ventilation [days]
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19 (11–30)
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90-day survival [%]
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72.2
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SOFA (0–24)
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12 (10–15)
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16 (12–18)
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15 (10–16)
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12 (5–16)
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APACHE II (0–71)
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32 (25–36)
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34 (26–39)
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32 (29–38)
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31 (23–36)
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PaO2/FiO2 [mmHg]
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122 (87–189)
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102 (89–158)
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138 (106–167)
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149 (132–198)
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White blood count [103/µl] (5–10)
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9.2 (6.6–11.3)
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10.7 (7.7–16.1)
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11.9 (7.4–16.3)
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11.1 (10.0-15.8)
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Red blood count [106/µl] (4–6)
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3.58 (3.14–3.81)
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3.11 (2.91–3.45)
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3.21 (2.91–3.28)
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3.02 (2.74–3.30)
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Hemoglobin [g/dl] (female: 12–16, male: 14–18)
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10.0 (8.9–11.1)
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9.1 (8.3–10.0)
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9.0 (8.6–9.2)
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9.2 (8.5–9.4)
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Hematocrit [%] (female: 35–47, male: 42–50)
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32.4 (28.3–33.8)
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29.0 (26.2–31.1)
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29.9 (27.2–30.5)
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27.5 (26.0-30.1)
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Platelet count [103/µl] (150–450)
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211 (131–282)
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206 (145–232)
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232 (165–340)
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261 (181–328)
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Mean platelet volume [fl] (9.7–11.9)
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11.0 (10.3–11.8)
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11.1 (10.6–11.5)
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11.5 (11.2–12.0)
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11.8 (11.1–13.1)
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aPTT [sec] (23–36)
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39.6 (37.5–46.2)
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46.4 (40.2–56.6)
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50.6 (32.9–58.2)
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42.5 (31.3–54.1)
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PT [sec] (10–12) (n = 17)
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11.9 (10.1–12.4)
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11.9 (10.2–12.2)
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11.2 (10.2–12.0)
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11.8 (10.5–12.3)
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INR (0,85 − 1,18)
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0.99 (0.94–1.06)
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1.01 (0.94–1.06)
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0.98 (0.93–1.04)
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1.04 (0.99–1.08)
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Quick [%] (70–130)
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94 (88–112)
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94 (86–113)
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103 (92–118)
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100 (88–108)
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Fibrinogen [g/l] (2.1-4.0)
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6.0 (5.5–7.2)
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6.5 (5.7–7.5)
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6.1 (4.8–8.4)
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5.6 (5.0-6.9)
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D-dimer [mg/l] (< 0.5)
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4.7 (2.6–7.3)
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2.9 (1.7–5.4)
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4.5 (2.3–8.6)
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7.2 (4.5–11.4)
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AT [%] (75–125 %)
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79 (73–90)
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91 (79–103)
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106 (87–119)
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96 (77–108)
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DIC Score (n = 17)
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3 (3–3)
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3 (2–3)
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3 (3–3)
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3 (3–3)
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IL-6 [pg/ml] (< 7)
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224 (127–511)
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247 (81–547)
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101 (27–212)
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74 (37–308)
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C-reactive protein [mg/dl] (< 0.5)
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23.3 (16.1–27.7)
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25.14 (14.3–32.5)
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18.8 (7.7–29.1)
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13.4 (7.7–17.5)
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Procalcitonin [ng/ml] (< 0.5)
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1.53 (0.72–3.62)
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1.85 (0.50–6.27)
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1.45 (0.39–3.86)
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1.83 (0.27–2.32)
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Creatinine [mg/dl] (< 1.17)
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1.08 (0.80–1.85)
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1.08 (0.80–1.85)
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1.24 (0.81–2.02)
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1.06 (0.86–1.58)
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Anti-Xa level [IU/mL]
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0.46 (0.13–0.78) (n = 2)
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0.38 (0.21–0.55) (n = 5)
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0.46 (0.32–0.60) (n = 7)
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0.59 (0.37–0.76) (n = 4)
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- Clinical characterization and laboratory values of ICU patients (total n=18) in course of ICU stay.
- Clinical scores and laboratory values at days 1, 4, 7 and 14 after admission to ICU. Values are expressed as median and IQR. Disseminated Intravascular Coagulation (DIC) scores are calculated from platelet count, prothrombin time, fibrinogen and D-dimers according to guidelines of the International Society on Thrombosis and Haemostasis (ISTH) [35]. Units are displayed in square brackets and reference values in round brackets. Abbreviations: SOFA Sequential Organ Failure Assessment Score, APACHE II Acute Physiology And Chronic Health Evaluation Score II, PaO2 oxygen partial pressure, FiO2 fraction of inspired oxygen, aPTT activated Partial Thromboplastin Time, PT Prothrombin Time, INR International Normalized Ratio, AT Antithrombin, IL-6 Interleukin 6.
