You are viewing the site in preview mode

Skip to main content

Table 1 Summary of laboratory findings on NM at presentation and after each course of Intravenous Immunoglobulin demonstrating transient improvement

From: Combination of acquired von Willebrand syndrome (AVWS) and Glanzmann thrombasthenia in monoclonal gammopathy of uncertain significance (MGUS), a case report

Laboratory parameter Reference range Presentation First course IVIg Second course IVIg Third course IVIg
Full Blood Count
 Haemoglobin 12.4–16.7 g/dL 3.5 14.7 13.1 12.7
 Haematocrit 0.35–0.49 UL 0.12 0.48 0.38 0.40
 Red cell Count 3.8–5.5 × 109/L 1.29 5.56 4.88 4.43
 Mean Cell Volume 79–100 fL 89.90 85.60 85.60 89.40
 Mean Cell Haemoglobin 27–35 pg 27.10 26.50 26.80 28.70
 Mean Cell Haemoglobin concentration 29 - 37 g/dL 30.20 31.30 31.30 32.10
 White Cell Count 4-12 × 109/l 4.52 5.14 4.70 2.62
 Platelet Count 150-450 × 109/L 310 245 245 187
 Red cell distribution width 11.0–16.0 22.80 14.10 14.10 13.20
Reticulocyte production
 Reticulocyte production index 1.00–1.25 2.2    0.9
Iron Studies
 Ferritin 20-300 ng/mL 7    11
Coagulation studies
 INR 1.00–1.25 1.06    1.02
 Prothrombin Time < 14 s 13.2   11.8 14.6
 Activated Partial Thromboplastin Time 27–43 s 52.7    35.4
 Fibrinogen 1.7–4.2 g/L 3.5    3.8
Factor VII levels
 Factor VIII 50–150% 6 48 (7a) 78 (15a) 88 (22a)
 Factor VII inhibitor Bethesda 0    0
Von Willebrand Factor Screen
 Von Willebrand Factor Activity 47.8–173.2% 15    32 (6a)
 Von Willebrand Factor Antigen 50–160% 10 52 (10a) 51 (14a) 43 (10a)
Platelet studies
 Agonist - ristocetin 0.5μg/mL No response Normal   Normal Normal
 Agonist - ristocetin 1.5μg/mL 60–110% 5 10 10 32 (10a)
 ADP 5.0 uM 60–100% 17    
 Epinephrine 10μg/mL 60–110% 14    
 Collagen 2μg/mL 60–110% 3    
 Arachidonic Acid   Decreased    
Platelet function analyser
 Collagen/Epinephrine 82–150 > 300    
 Collagen /Adenosine diphosphate 62–100 > 300    
Liver function tests
 Albumin 35–50 g/L 28    
 Bilirubin (unconjugated) 3-6umol/L 4    
 Bilirubin (conjugated) 2–7 umol/L 3    
 AST 13–35 IU/L 8    
 ALT < 35 IU/L 3    
IgM paraprotein g/L 3 4   4
Urea and Electrolytes
 Sodium 136-145 mmol/L 136    
 Potassium 3.5–5.1 mmol/L 4.5    
 Chloride 98-107 mmol/L 108    
 Total CO2 21-29 mmol/L 23    
 Urea 2.9–8.2 mmolL 2.5    
 Creatinine 53–97 umol/L 36    
Bone Marrow Aspirate Clonal plasma cells present but < 5% of cells. Iron stores absent.
  1. aResults prior to administration of intravenous immunoglobulin where appropriate
Back to article page

Thrombosis Journal

ISSN: 1477-9560

Contact us