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CHADS2 score
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Scoring system
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Stroke rates associated with CHADS2 score
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Risk factor
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Points
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Risk score
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Adjusted stroke rate (%/y)a, b (95 % CI)
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Risk of stroke
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C
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CHF
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1
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0
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1.9 (1.2, 3.0)
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Low
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H
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Hypertension
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1
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1
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2.8 (2.0, 3.8)
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Moderate
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A
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Age ≥75 y
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1
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2
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4.0 (3.1, 5.1)
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D
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Diabetes
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1
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3
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5.9 (4.6, 7.3)
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S2
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Prior stroke/TIA
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2
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4
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8.5 (6.3, 11.1)
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High
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5
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12.5 (8.2, 17.5)
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6
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18.2 (10.5, 27.4)
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CHA2DS2-VASc score
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Scoring system
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Stroke rates associated with CHA2DSs-VASc score
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Risk factor
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Points
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Risk score
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TE rate during 1 year (% [95 % CI])c, d
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Risk of stroke
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C
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CHF/LV dysfunction
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1
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0
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0
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Low
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H
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Hypertension
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1
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1
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0.6 (0.0, 3.4)
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Moderate
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A2
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Age ≥75 y
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2
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2
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1.6 (0.3, 4.7)
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D
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Diabetes
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1
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3
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3.9 (1.7, 7.6)
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High
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S2
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Prior stroke/TIA/TE
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2
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4
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1.9 (0.5, 4.9)
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V
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Vascular disease (prior MI, PAD, or aortic plaque)
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1
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5
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3.2 (0.7, 9.0)
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A
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Age 65–74 y
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1
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6
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3.6 (0.4, 12.3)
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Sc
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Sex category (female sex)
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1
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7
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8.0 (1.0, 26.0)
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CHF congestive heart failure, CI confidence interval, LV left ventricular, MI myocardial infarction, PAD peripheral artery disease, TE thromboembolism, TIA transient ischemic attack
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aAdapted from Gage BF et al. JAMA. 2001;285:2864–70 [33]
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bAdjusted stroke is expected stroke rate per 100 person-years from exponential survival model, assuming no aspirin was taken
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cAdapted from Lip GYH et al. Chest. 2010;137:263–72 [34]
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dp value for trend = 0.003